Human trabecular meshwork cell volume regulation
نویسندگان
چکیده
منابع مشابه
Human trabecular meshwork cell volume regulation.
The volume of certain subpopulations of trabecular meshwork (TM) cells may modify outflow resistance of aqueous humor, thereby altering intraocular pressure. This study examines the contribution that Na+/H+, Cl-/HCO exchange, and K+-Cl- efflux mechanisms have on the volume of TM cells. Volume, Cl- currents, and intracellular Ca2+ activity of cultured human TM cells were studied with calcein flu...
متن کاملModulation of aqueous humor outflow by ionic mechanisms involved in trabecular meshwork cell volume regulation.
PURPOSE Trabecular meshwork (TM) cell shape, volume, contractility and their interactions with extracellular matrix determine outflow facility. Because cell volume seems essential to TM function, this study was conducted to investigate further the ionic channels and receptors involved in regulatory volume decrease and their roles in modulating outflow facility. METHODS Primary cultures of bov...
متن کاملDown-regulation of GRP78 in human glaucomatous trabecular meshwork cells
PURPOSE Since the 78 kDa glucose-regulated protein (GRP78) is a key marker of endoplasmic reticulum (ER) stress, we investigated and analyzed GRP78 expression levels in the trabecular meshwork (TM) by eyes with primary open angle glaucoma (POAG) and normal eyes to understand the role of GRP78 in human TM cells apoptosis. METHODS Trabecular meshwork cells from POAG patients (GTM) and age-match...
متن کاملNO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.
Nitric oxide (NO) donors decrease intraocular pressure (IOP) by increasing aqueous outflow facility in the trabecular meshwork (TM) and/or Schlemm's canal. However, the cellular mechanisms are unknown. Cellular mechanisms known to regulate outflow facility include changes in cell volume and cellular contractility. In this study, we investigated the effects of NO donors on outflow facility and N...
متن کاملExpression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume.
PURPOSE Drainage of aqueous humor from the human eye appears dependent on intracellular volume of trabecular meshwork (TM) cells, the predominant cell type of the human outflow pathway. Thus, the modulation of water and solute flux across the plasma membrane of TM cells is predicted to be an important factor in regulating outflow facility. Aquaporin (AQP)-1 is a hexahelical integral membrane pr...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2002
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00544.2001